Officers acting under warrant entered seven properties in Galashiels and seized drugs, cash and electronic equipment on Tuesday, 27 April.
A quantity of heroin, believed to be worth more than £250,000, was seized from a house in the town’s Laidlaw Court.
A 39-year-old man has been arrested in connection with drugs offences and is due to appear at Jedburgh Sheriff Court today.
A further four men, aged 24, 28, 32, and 43 will be subject of a report to the Procurator Fiscal.
Detective Chief Inspector Bryan Burns said: “Through effective intelligence gathering, the help and support from the local community we continue to cause considerable disruption to the supply of drugs in the Scottish Borders and associated organised crime.
"We will continue to investigate those who profit from, and care nothing for, the misery that drugs bring to individuals, their families and communities."