Head coach Gregor Townsend has picked Cameron Redpath to make his debut for the Scots.
The Bath player, who previously represented England at under-20 level, will start at inside centre.
Redpath, who was born in France, decided to commit his international future to Scotland.
He was named in the full England squad to tour South Africa in 2018 but had to pull out due to injury.
The son of former Scotland captain Bryan Redpath, he will partner Chris Harris in the centre against England.
Elsewhere, hooker George Turner will make his Six Nations bow, with the uncapped Dave Cherry on the bench as back-up.
Here’s the full team plus substitutes:
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9. Ali Price
Scrum-half, Glasgow Warriors. Date of birth: 12/05/93. Height: 1.78m. Scotland Debut: September 2016. Place of birth: Norfolk England. Weight: 85.5kg Photo: Craig Williamson - SNS Group / SRU
10. Finn Russell
Fly-half, Racing 92. Date of birth: 23/09/92. Height: 1.83m. Scotland Debut: June 2014. Place of birth: Bridge of Allan. Weight: 92kg Photo: Craig Williamson - SNS Group / SRU
11. Duhan van der Merwe
Left-wing, Edinburgh Rugby.Date of birth: 4/6/95. Height: 6'4. Scotland Debut: October, 2020. Place of birth: George. Weight: 106.1kg Photo: Craig Williamson - SNS Group / SRU
12. Cameron Redpath
Inside Centre, Bath. Date of birth: 23/12/99. Height: 6'2. Scotland Debut: Uncapped. Place of birth: Narbonne, France. Weight: 95kg Photo: Craig Williamson - SNS Group / SRU