Head coach Gregor Townsend has picked Cameron Redpath to make his debut for the Scots.
The Bath player, who previously represented England at under-20 level, will start at inside centre.
Redpath, who was born in France, decided to commit his international future to Scotland.
He was named in the full England squad to tour South Africa in 2018 but had to pull out due to injury.
The son of former Scotland captain Bryan Redpath, he will partner Chris Harris in the centre against England.
Elsewhere, hooker George Turner will make his Six Nations bow, with the uncapped Dave Cherry on the bench as back-up.
Here’s the full team plus substitutes:
Message from the editor: Get a year of unlimited access to all The Scotsman's sport coverage without the need for a full subscription. Expert analysis of the biggest games, exclusive interviews, live blogs, transfer news and 70 per cent fewer ads on Scotsman.com - all for less than £1 a week. Subscribe to us today HERE
5. Jonny Gray
Lock, Glasgow Warriors. Date of birth: 14/03/94. Height: 1.99m. Scotland Debut: November 2013. Place of birth: Rutherglen. Weight: 121kg. Photo: Craig Williamson - SNS Group / SRU
6. Jamie Ritchie
Flanker, Edinburgh Rugby. Date of birth: 16/08/96. Height: 1.93m. Scotland Debut: June 2018. Place of birth: Dundee. Weight: 105kg. Photo: Giuseppe Maffia - SNS Group
7. Hamish Watson
Openside Flanker, Edinburgh Rugby. Date of birth: 15/10/91. Height: 1.85m. Scotland Debut: March 2015. Place of birth: Manchester, England. Weight: 102kg Photo: Craig Williamson - SNS Group / SRU
8. Matt Fagerson
Number 8, Glasgow Warriors. Date of birth: 16/07/98. Height: 1.85m. Scotland Debut: June 2018. Place of birth: Perth. Weight: 102kg Photo: Craig Williamson - SNS Group / SRU