Head coach Gregor Townsend has picked Cameron Redpath to make his debut for the Scots.
The Bath player, who previously represented England at under-20 level, will start at inside centre.
Redpath, who was born in France, decided to commit his international future to Scotland.
He was named in the full England squad to tour South Africa in 2018 but had to pull out due to injury.
The son of former Scotland captain Bryan Redpath, he will partner Chris Harris in the centre against England.
Elsewhere, hooker George Turner will make his Six Nations bow, with the uncapped Dave Cherry on the bench as back-up.
Here’s the full team plus substitutes:
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1. Rory Sutherland
Prop, Edinburgh Rugby. Date of birth: 24/08/92. Height: 1.83m.Scotland Debut: 2016. Place of birth: Melrose. Weight: 113kg Photo: Brendan Moran - SNS Group
2. George Turner
Hooker, Glasgow Warriors. Date of birth: 08/10/92. Height: 1.80m. Scotland Debut: September 2017. Place of birth: Edinburgh. Weight: 105kg Photo: Craig Williamson - SNS Group / SRU
3. Zander Fagerson
Prop, Glasgow Warriors. Date of birth: 19/01/96. Height: 1.88m Scotland Debut: March 2016. Place of birth: Perth. Weight: 126kg Photo: Craig Williamson - SNS Group / SRU
4. Scott Cummings
Lock, Glasgow Warriors. Date of birth: 03/12/96. Height: 1.98m. Scotland Debut: Uncapped. Place of birth: Glasgow. Weight: 116kg Photo: Craig Williamson - SNS Group / SRU