After last week’s manic encounter which ended in a 4-3 win for the Scottish Premiership leaders, the Ibrox boss is without striker Kemar Roofe and captain James Tavernier.
Rangers got off to the ideal start with Ryan Kent chasing down possession and squaring for Alfredo Morelos to open the scoring inside nine minutes.
They were pegged back with a flick by Lior Rafeleov but the game exploded into life just 17 seconds after the restart with Nathan Patterson firing in the best possible apology for his COVID misdemeanour earlier this week.
The youngster was excellent in replacing Leon Balogun and Rangers went further ahead with a fantastic third involving all three forwards.
Lamkel Ze pulled one back after Connor Goldson clattered Allan McGregor but Rangers pressed on and two penalties from Borna Barisic and sub Cedric Itten put Rangers into the last 16.
Here’s how the Rangers players rated using our scale.
Player ratings scale - 10: One of the best performances you've seen. 9: Outstanding. 8: Very good. 7: Good. 6: Average. 5: Poor, 4: Very poor. 3: A terrible day at the office. 2: Abysmal. 1: One of the worst performances you've seen.
A message from the Editor:Get a year of unlimited access to all The Scotsman's sport coverage without the need for a full subscription. Expert analysis of the biggest games, exclusive interviews, live blogs, transfer news and 70 per cent fewer ads on Scotsman.com - all for less than £1 a week. Subscribe to us today.
1. Allan McGregor - 7
Steady at the back despite conceding twice - Rangers would look so much weaker without him Photo: Rob Casey - SNS Group
2. Leon Balogun - 5
Looked uncomfortable and had to be substituted with an injury and replacement Patterson made a big impact. Booking rules him out of next round first leg. Photo: Craig Foy - SNS Group
3. Borna Barisic - 7
Left-back was on the scoresheet again and played a more leading role and looks comfortable shouldering the responsibility. Photo: SNS Group
4. Connor Goldson - 7
Held the defence together and took one for the team in colliding with McGregor when Antwerp pulled one back. Photo: Craig Foy - SNS Group