Emergency services were called to the scene on the A9 north of Tomatin, Highland, just after 7.35am on Thursday.
The Scottish Ambulance Service said five adults were taken to Raigmore Hospital in Inverness. They are not believed to be seriously injured.
The road was closed in both directions for a time to allow recovery of the vehicles, police said.
The crash is the latest in a string of accidents on the route in recent years.
Last month 15-year-old Hollie Mackay died after she was hit by a car on the road at Invergordon, Highland, while in July a crash involving two cars killed three people near Kingussie, Highland.
The Scottish Government has pledged to upgrade the A9 - which is the main route to the Highlands - to a dual carriageway by 2025, with a £3 billion project to convert 80 miles of the road.
Plans to install average speed cameras along the road from Dunblane to Inverness, at a cost of £2.5 million, have also been announced and they are expected to be fully operational by next summer.