The Glasgow-born artist passed away in the early hours in Athens, according to reports from her team.
A official statement provided to the music magazine NME read:
"It is with profound sadness that I have to inform you that musician and producer SOPHIE passed away this morning around 4am in Athens, where the artist had been living, following a sudden accident. At this time respect and privacy for the family is our priority. We would also ask for respect for her fanbase, and to treat the private nature of this news with sensitivity.
"SOPHIE was a pioneer of a new sound, one of the most influential artists in the last decade. Not only for ingenious production and creativity but also for the message and visibility that was achieved. An icon of liberation."
Sophie collaborated on music with many leading musicians, including Madonna and Lady Gaga.
She was one of the first openly trans women to be nominated for a Grammy for her debut album, Oil Of Every Pearl’s Un-Insides, was released in 2018.
The same year she featured in NME’s top 10 musicians leading pop’s queer revolution.
Tributes have been shared online following news of her death.
Berlin-based record label PAN tweeted: “Rest in power you incredible human”.
Christine and the Queens wrote: “She rebelled against the narrow, normative society by being an absolute triumph, both as an artist and as a woman. I can’t believe she is gone.
“We need to honour and respect her memory and legacy. Cherish the pioneers.”