The 40-year-old Scot was being interviewed about his latest movie when he admitted he's keen on the coveted role.
And the Balmaclellan-born star of Outlander revealed he has actually tried out for the part before.
Speaking to the Radio Times, Heughan recalled auditioning to be the iconic spy prior to Daniel Craig's official casting in October 2005.
“I met [producer] Barbara Broccoli and [Casino Royale director] Martin Campbell,” he said.
“I did a scene and they had the gun from The Man with the Golden Gun on the table and I remember thinking, ‘Wow, this is incredible’.
“It was surreal,” he added. “He’s a character we’ve all grown up with.”
A host of big-name actors have been linked with the iconic role since the announcement that Craig will be stepping down.
Stars including Idris Elba, Tom Holland, James Norton and Tom Hardy have all been suggested as contenders.
And when Craig’s stint as Bond comes to an end with this September’s No Time To Die, Heughan would be more than willing to audition again.
“I don’t think any actor would ever say no,” he said. “If I was asked to audition for it, I would be delighted.”
Heughan stars alongside Andy Serkis and Ruby Rose in new film SAS: Red Notice, and his role as special forces operator Tom Buckingham is not too dissimilar to 007.
“You have to draw parallels, because it’s a similar world,” he said. “I feel like our movie is a bit of Bond and a bit of Bourne.”