The event, which takes place every autumn to raise money for vulnerable children and young people across Scotland, is celebrating its tenth year.
The hour-long programme will be broadcast on STV at 8:30pm on Friday October 16, and will be available to watch UK-wide on the STV Player.
Ayrshire rock trio Biffy will perform latest single Space, taken from new album A Celebration of Endings.
Elsewhere Godley, the comic and actress who creates hilarious voiceovers of Nicola Sturgeon’s daily coronavirus briefings, will bring some humour to proceedings.
The STV Children’s Appeal 2020 will also feature a one-off Celebrity Catchphrase special with Strictly Come Dancing winner Kelvin Fletcher, broadcaster Steph McGovern and funnyman Tom Allen all trying to guess familiar phrases alongside host Stephen Mulhern.
Presenter Kelly said: “This is our tenth STV Children’s Appeal show and the generosity of the big-hearted people of Scotland never fails to amaze me.
"That support is needed now more than ever, as this awful pandemic has made life even more difficult for the one in four children living in poverty across the country."
“The show is a bit different this year as I’m not going to be presenting live from the studio in Glasgow, but I can still promise a must-see night of fun and games, A-list music talent, and heartwarming reminders of the unwavering kindness and generosity of the Scottish people.”
Viewers can donate £5 to the STV Children’s Appeal by texting FIVE to 70607 (standard network rates apply).