Officers searched a property in John Lang Street as part of an intelligence-led operation on 29 April.
During the search, significant quantities of heroin, cocaine and herbal cannabis were recovered.
A 27-year-old man has been arrested and charged in connection with drug offences.
He was due to appear in Paisley Sheriff Court today – Friday, 30 April.
Detective Sergeant David McIntosh said: “Drugs have absolutely no place in our community, and as a result of this operation, a significant quantity has been taken off the streets.
“Officers are out working every day to identify those seeking to supply drugs in the area and put a stop to this harmful activity.
“Support from members of the public is absolutely vital to this work and we would continue to encourage people to engage with us and pass on any relevant information.”