The Scottish producer was a passenger in a Cadillac on his way to the airport in Los Angeles when the vehicle collided with a Volkswagen Beetle at around 11pm local time on Friday, celebrity news website TMZ.com said.
The Feel So Close singer, whose real name is Adam Richard Wiles, had to pull out of a performance at the Omnia nightclub in Las Vegas as doctors recommended he take a few days off to recover.
A statement on the artist’s official Facebook page said: “Adam’s transport was involved in a collision this evening on the way to the airport. As a result he will be unable to perform at Omnia tonight.
“He has been examined by doctors and told to rest for a few days. Calvin HQ.”
The Beetle was reportedly driven by a 16-year-old girl and had crossed the centre line before the crash.
Harris, who is dating Taylor Swift, suffered a cut in the incident, according to TMZ.com.