Poulter is currently 42nd on the European Points list, but could still feature at Hazeltine as one of European captain Darren Clarke’s five vice-captains.
Clarke appointed Thomas Bjorn, Paul Lawrie and Padraig Harrington last week, with Poulter, Lee Westwood and Jose Maria Olazabal understood to be in contention for the remaining places.
“I am obviously disappointed to be in this situation, especially during a Ryder Cup year,” Poulter said in a statement. “Right now, rest and rehab take priority in me returning to full strength later this season. I look forward to resuming a full schedule as soon as I am able.”
Poulter’s doctor, Ara Suppiah, added: “Ian has been hampered by an arthritic joint in his right foot for the best part of two and a half years.
“The condition has progressed rapidly over the last year warranting numerous cortisone shots (within therapeutic limits) to allow him to play. Unfortunately, he continues to be in pain whilst walking and practicing.
“Further cortisone shots run the real risk of thinning the bones (osteopenia) and stress fractures, which might require treatment in a cast and significant time away from the game.
“We feel that the best option at this stage is to take some time off to allow complete recovery and rehabilitation (including customised orthotics and modification of footwear) of his foot. This will give him the best chance of returning to the game sooner and preventing further deterioration of the affected joint.”
Poulter has played in five Ryder Cups and been on the winning side four times, as well as finishing as the leading points scorer in the 2008 defeat at Valhalla.
The 40-year-old famously sparked the ‘Miracle at Medinah’ in 2012, carding five straight birdies to partner Rory McIlroy to victory in the Saturday afternoon fourballs against Jason Dufner and Zach Johnson.
Before the 2014 contest Poulter had won an incredible 80 per cent of his matches in the biennial contest, but he suffered his heaviest ever defeat in a 5&4 loss alongside Stephen Gallacher in the opening fourballs and halved his other two matches at Gleneagles.
Poulter did win all three of his matches in the EurAsia Cup in January, but is currently 85th in the world rankings and has not won a tournament since the WGC-HSBC Champions in 2012.