Six Nations: Italy return for Sergio Parisse after injury
The Azzurri take on Ireland on 5 February at the Stadio Flaminio before facing England at Twickenham one week later.
Mallett is without experienced pair Mauro Bergamasco and Craig Gower, both sidelined for the tournament by injuries.
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Hide AdInspirational captain Sergio Parisse returns to the squad having missed last year's entire tournament following injury.
Leicester's Martin Castrogiovanni is also in a squad that includes 11 players from Treviso.
Italy squad: Martin Castrogiovanni (Leicester Tigers), Andrea Lo Cicero (Racing Metro), Salvatore Perugini (Aironi), Ignacio Fernandez-Rouyet, Leonardo Ghiraldini (both Treviso), Fabio Ongaro (Aironi), Santiago Dellape (Racing Metro), Carlo Antonio Del Fava, Quintin Geldenhuys (both Aironi), Robert Barbieri, Paul Derbyshire (both Treviso), Sergio Parisse (Stade Francais), Alessandro Zanni (Treviso), Pablo Canavosio (Aironi), Edoardo Gori, Kristopher Burton, Luke McLean (all Treviso), Luciano Orquera (Brive), Tommaso Benvenuti (Treviso), Mirco Bergamasco (Racing Metro), Gonzalo Canale (Clermont), Gonzalo Garcia (Treviso), Andrea Masi (Racing Metro), Alberto Sgarbi (Treviso).