The sides will meet in Edinburgh on Saturday, February 5, with the home side defending the Calcutta Cup won earlier this year at Twickenham.
The opening round of fixtures for the 2022 Six Nations will also see Wales open their title defence against Ireland in Dublin on the same day. France will host Italy on Sunday, February 6.
Scotland will travel to Wales in round two on Saturday, February 12, and round three sees France visit Murrayfield on Saturday, February 26.
There will be a return of Friday night rugby in round four with Wales v France set to take place on March 11 at the Principality Stadium in Cardiff.
Scotland will face Italy in Rome on the following day.
Super Saturday will take place on March 19, starting with Wales v Italy followed by Ireland v Scotland and France v England.
No kick-off times have been announced, nor television details.
The TV deal with BBC and ITV expired at the end of the 2021 Six Nations. The tournament could move, in part, to pay TV with Amazon Prime Video understood to be in negotiations. It is expected that some of the competition will remain on terrestrial.
Scotland’s 2022 Guinness Six Nations fixtures:
Sat Feb 5: v England (h)
Sat Feb 12: v Wales (a)
Sat Feb 26: v France (h)
Sat Mar 12: v Italy (a)
Sat Mar 19: v Ireland (a)