Head coach Gregor Townsend has made some big calls, revamping the entire front row and bringing in Sione Tuipulotu for his first Six Nations start.
Tuipulotu replaces his Glasgow Warriors team-mate Sam Johnson at inside centre, with Johnson released to play for his club against Munster on Friday night.
The starting front row is the trio that finished the match against England last weekend. It means Pierre Schoeman, Stuart McInally and WP Nel replace Rory Sutherland, George Turner and Zander Fagerson who are all on the bench.
The other change is at blindside flanker where Sam Skinner of Exeter Chiefs comes in for the injured Jamie Ritchie.
Rory Darge is on the bench as back-row cover and is in line to win his first Scotland cap.
Cam Redpath is also added to the bench after recovering from a serious knee injury. The Bath centre has not played for Scotland since his impressive debut in last season’s Calcutta Cup win.
Scotland, who have not won in Cardiff for 20 years, are looking to build on their opening day victory over England.
Saturday’s match kicks off at 2.15pm at the Principality Stadium and is live on BBC One.
. The Scotland team prepares for Saturday's match against Wales in Cardiff.
The Scotland team prepares for Saturday's match against Wales in Cardiff. Photo: Craig Williamson - SNS Group / SRU
. Pierre Schoeman
A first Six Nations start for the loosehead, who is picked ahead of Rory Sutherland. Photo: Craig Williamson - SNS Group / SRU
. Stuart McInally
Replaces George Turner at hooker after coming off the bench against England. Photo: Ross Parker - SNS Group / SRU
. WP Nel
Veteran prop is part of a new-look, all-Edinburgh front row as the ‘finishers’ from the England game are given the opportunity to start against Wales. Photo: Ross Parker - SNS Group
1. Pierre Schoeman
A first Six Nations start for the loosehead, who is picked ahead of Rory Sutherland. Photo: Craig Williamson - SNS Group / SRU
2. Stuart McInally
Replaces George Turner at hooker after coming off the bench against England. Photo: Ross Parker - SNS Group / SRU
3. WP Nel
Veteran prop is part of a new-look, all-Edinburgh front row as the ‘finishers’ from the England game are given the opportunity to start against Wales. Photo: Ross Parker - SNS Group
4. Jonny Gray
Retains his place as Gregor Townsend sticks with same second row combinations. Photo: Ross Parker - SNS Group