The Scotland international scrum-half has not played since injuring his foot in December and is one of six changes for Glasgow’s final match of the truncated Pro14 season.
“We’ve not seen George since Leinster at home, so it’s great to have him back,” said Wilson. “He’s busting to play. Like all of them returning we’ve just got to be a little bit patient, but he’ll be chomping at the bit to get out there and show what he’s made of.”
Horne’s older brother, Pete, drops out the side and is replaced by Robbie Fergusson at inside centre while Ollie Smith returns at full-back instead of Adam Hastings who was on Scotland duty.
James Scott comes into the second-row, with Kiran McDonald shifting to the blindside to accommodate him. Ryan Wilson’s late Scotland call-up means it’s all change in the back-row with Fotu Lokotui promoted from the bench to start at openside and TJ Ioane at No 8.
Glasgow are looking to hold on to fourth place in Conference A but have Dragons breathing down their necks. The Welsh side host Edinburgh on Sunday.
Wilson, meanwhile, has revealed that Scott Cummings could be out for almost two months. The Scotland lock suffered a hand injury against Ireland and a scan has revealed a fracture.
“He had a break in his hand so he will be six to eight weeks out,” said Wilson.
Glasgow have also lost No 8 Matt Fagerson who injured his ankle while training with Scotland.