The Northern Irishman has not lost in eight matches against the Light Blues since he took over at Parkhead in 2016 and has won three out of three in Govan.
Celtic sit six points clear of their old rivals at the top of the Ladbrokes Premiership with a game in hand, as they look to secure their second successive domestic treble.
Following their 3-0 home win over Morton in the William Hill Scottish Cup quarter-final last week, Rodgers’ squad will enjoy a rare free week to prepare for the game against a Rangers side and support who have grown in confidence with recent form, having lost only once in 12 games.
“We’ve got a lot of work to do and we’ll need to perform better and more consistently in that game,” the Northern Irishman told the club’s official website.
“But we’ve gone there three times before and performed very well.
“There’s huge pressure on Rangers in the game but for us, we’ll have a good working week and go into that game and work as well as well can.
“Having a full week’s preparation will make a massive difference. The objective on Saturday was to get the game done and get through to the semi-final.
“It will be a tough game for us at Ibrox, of course, but we’ll get ready. We’ll work some elements of where we can hurt them and prepare really well for that and go there with confidence.
“They’ve got a bit more spirit, from what I see, and they’ve probably found a consistency, but they’ve played without pressure for most of my time up here so they’ll feel this little bit of pressure in the game because it’s a game they have to win.
“We want to win it, of course, the same as every game we play, and especially against our rivals.”