The 21-year-old, who won two bronze and a silver in the 2016 Games in Rio, will join fellow Scot and 2016 club throw gold medallist Jo Butterfield, of Glasgow, as part of the GB representation.
Lyle will compete T35 100 and 200 metres following two bronze medals in Brazil five years ago. The pair join a list of six reigning champions at the Games including Hollie Arnold, Richard Whitehead and Sophie Hahn.
Team GB Para athletics head coach Paula Dunn said: "It has been a long wait for these athletes, but this is a significant milestone in their career, so I hope they savour this moment and reflect on their achievement so far and use it to fuel them in the final few weeks of preparation for the Games.
“I am proud of how these athletes have conducted themselves over the last year or so under very challenging circumstances.”