The disappointing news for the Nairn player comes just a few weeks after he was named as the sole Scot in a 10-strong side being led into battle at Seminole in Florida early next month by Stuart Wilson the former Amateur champion from Forfar.
Scott, the world No 8, and Alex Fitzpatrick, the younger brother of European Tour player Matt, had been the only survivors from a 15.5-10-5 defeat at Royal Liverpool in 2019.
His place has been filled by Englishman Jack Dyer, with Florida-based Joe Pagdin, another English player, added as second reserve.
“It’s obviously a bit of a blow losing Sandy as he was an automatic pick for the highest-ranked player on WAGR and having performed well in the previous match,” said Wilson. “We knew of Sandy's injury and he was keeping us informed of his progress.
"Unfortunately, Sandy had to inform us that he didn't think he would be ready and we are thankful to him for making an early call on that with the team’s best interests at heart and we wish him a full recovery.
“On a positive slant, though, we are in a strong position that we have the depth to now be able to bring in Jack Dyer, who had been showing some great form earlier in the year out in South Africa.
“It is also great news for us that Joe Pagdin will be with the team for the week now, too.”
In addition to Fitzpatrick, 23-year-old Dyer joins compatriots Barclay Brown, Angus Flanagan, Ben Jones, Matty Lamb, Joe Long and Ben Schmidt in the starting line up, which is completed by Irish pair John Murphy and Mark Power.