The King’s Course at the Perthshire resort will host the 35th edition of the tournament from 21-24 July, 2022.
Gleneagles is no stranger to elite golf events, having hosted the 2014 Ryder Cup and the 2019 Solheim Cup, as well as 26 European Tour events since 1974.
Johnnie Cole-Hamilton, Executive Director – Championships at The R&A, said: “This is another great ‘first’ in the history of The Senior Open and we could not be more thrilled to be staging the championship on The King’s Course at Gleneagles.
"With such a strong pedigree in hosting championships, The King’s is a fine test of golf and we know the players will relish the opportunity to play there.
“Adding another renowned venue to the roster is a clear indication of the continuing development of The Senior Open and I’m sure there will be a real sense of anticipation among the players and fans for our first visit to Gleneagles in two years’ time.”
The event will follow the 150th Open Championship at St Andrews while 2022 will also see the AIG Women's Open being held at Muirfield for the first time.
“I’m delighted that The Senior Open Championship will be returning to Scotland at Gleneagles in 2022, continuing the long and successful association between Scotland, the Home of Golf, and the Championship and supporting the recovery of our golf tourism and events sector, said Paul Bush, Director of Events at VisitScotland.
“Gleneagles has hosted some of the sport’s biggest events and will provide a superb venue for such a prestigious Championship.
"Alongside The Open and the AIG Women’s Open, The Senior Open Championship will form part of an unrivalled summer of golf in Scotland in 2022, with three major championships alongside our regular events proving that Scotland is the perfect stage for major events.”
The last time the Senior Open visited Scotland was in 2018, when Miguel Ángel Jiménez secured a one-stroke victory over Bernhard Langer on the Old Course at St Andrews.
By 2022, a host of golfing stars will be eligible to compete in their first Senior Open, including European Ryder Cup captains Thomas Bjørn and Padraig Harrington.