They haven't faced each other since the 2019 World Cup in France but Scotland will finally lock horns with England again this Friday as they begin their inaugural UEFA Womens Nation's League campaign in Sunderland.
Pedro Martinez Losa's side head into the Auld Enemy clash full of confidence after winning their last four games and with over 40,000 fans expected at the Stadium Of Light, it is certain to be an occasion to remember for both sides.
Scotland have been buoyed by the return of captain Rachel Corsie from injury, while youngsters Lauren Davidson, Emma Watson and Kirsty MacLean have Tartan Army fans dreaming of an upset in the North East of England.
As Corsie admitted though, the Lionesses will be a real tough task for Losa's side. Winners of the European Championship last summer, they were inches away from adding the World Cup trophy trophy to their honours in Australia this summer.
With a packed out home end and a dedicated Scotland away end for the first time, the game is being met with much anticipation. We predict which starting XI Scotland will go with as they look to topple the Lionesses on Friday.
1. GK - Lee Gibson
The undisputed best goalkeeper in Scotland will start at the Stadium of Light on Friday. Photo: LIONEL BONAVENTURE
2. RB - Rachel McLauchlan
The Rangers right back has enjoyed a good start to the season at domestic level and should begin the game at right back.
3. CB - Rachel Corsie
Frustratingly missed the last camp through a niggle but will lead the team out in Sunderland. Photo: Ross MacDonald - SNS Group
4. CB - Sophie Howard
Alongside Corsie will be Scotland's Mrs Reliable from Leicester City. Photo: Lukasz Skwiot - SNS Group / SFA