For Celtic it is about trying to win and get out of the current wretched form, while Rangers will be looking to get a win to finish top of their group and give them a better chance at getting a more favourable draw in the knockout stages.
Domestically, the weekend will begin a frantic period, especially for Premiership teams still in the Betfred Cup with plenty of midweek matches on the horizon with a typically full festive schedule and no winter break.
We will have all the latest from around the SPFL throughout the day as it happens, including transfer talk.
Scottish Football LIVE: Latest news and transfers
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Michael Gardyne has denied uttering a homophobic slur directed at Rangers players on Sunday.
The Ross County player was accused of comments during the 4-0 loss to the Ibrox side.
They are set to be investigated by the SFA’s compliance officer but a representative of the player told the Daily Record there is no truth in the allegations and that they are “absolutely ludicrous”.
There will be interest in James Tavernier from around Europe, reckons former England goalkeeper Paul Robinson.
The Rangers right-back has been one of the players of the season and has scored 16 goals.
Robinson told Football Insider: “Tavernier’s form will be attracting the attention of club’s across Europe.
“It is an incredible return for a right-back. The goal return alone is absolutely incredible for a defender let alone with the assists."
Karamoko Dembele has left staff at Celtic disappointed, report The Athletic.
There are concerns about the player’s application and attitude.
Dembele has not been involved much with the first-team lately in terms of matchday squads.
Reports in Spain, however, suggest there is interest from Barcelona, Real Madrid and Borussia Dortmund.