Steven Gerrard saw his Rangers side defeated for the first time in Europe this term and just the second defeat in all competitions.
Slavia Prague will take a place among the last eight teams in this season’s Europa League after a powerful first half header from Peter Olayinka and then a stunning free-kick from Nicolae Stanciu.
But the story of the second half was a pair of red cards for Rangers players Kemar Roofe and Leon Balogun which took the wind out of the home side’s sails as they rallied and tried to level the tie on aggregate.
However it was the end of the road at the round of 16 for the second consecutive season.
Here is how Rangers players rated.
Player ratings scale - 10: One of the best performances you've seen. 9: Outstanding. 8: Very good. 7: Good. 6: Average. 5: Poor, 4: Very poor. 3: A terrible day at the office. 2: Abysmal. 1: One of the worst performances you've seen.
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1. Allan McGregor - 6
Unlucky with the opener but well beaten for the second and Stanciu's stunning free-kick. Didn't do much wrong but Rangers still hung in there because of his heroics in the first leg. Photo: Alan Harvey - SNS Group
2. Nathan Patterson - 8
Young right-back was targeted last week but grew into the task and Slavia didn't make the same mistake this time. Unlucky with a shot when down to 10 men and some excellent timed tackles before being taken off, presumably for a rest ahead of the Old Firm match. Photo: Rob Casey - SNS Group
3. Borna Barisic - 7
Left-back sent in several tantalising crosses in the first half but there were no takers. Drifted inside to support Balogun when Slavia attacked before the backs went to the wall down to nine men. Photo: SNS Group
4. Leon Balogun - 4
Red card sealed the exit but was fortunate not to be punished for a clumsy tackle on Sima at the end of the first half in the penalty box. Drafted in for the slightly injured Helander and pressed hard when the ball was on his unnatural side. Photo: Craig Foy - SNS Group