The Rangers boss has made three changes to the side which defeated St Johnstone 1-0 during the week, courtesy of goal form Ianis Hagi.
There are starts for Bongani Zungu and Cedric Itten, while Glen Kamara is restored to the starting XI after being named amongst the subs in midweek.
Out go Ryan Jack, Steven Davis and Kemar Roofe, who all start on the bench alongside new signings Scott Wright and Jack Simpson.
The league leaders can extend their lead over rivals Celtic back to 23 points following Saturday’s 2-1 win over Motherwell for Neil lennon’s men.
The match in Hamilton gets underway at 12pm on Sky Sports,
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1. Allan McGregor
The veteran continues to show his class between the sticks. Photo: Rob Casey - SNS Group
2. James Tavernier
17 goals, 11 assists. Not scored in 11 but has shown his defensive qualities of late. Photo: Alan Harvey - SNS Group
4. Filip Helander
The Swede has brought some top-level experience to the Rangers backline and it has showed. Photo: Alan Harvey - SNS Group