Giovanni van Bronckhorst’s men are level with PSV following a 2-2 draw in the first-leg at Ibrox.
They will have to do so without the services of Alfredo Morelos; the Colombian has been left out of the squad, while Glen Kamara returns following his absence for the 2-2 Premiership draw with Hibs at the weekend.
The game with PSV is one of three Champions League qualifiers this evening with 29 of the 32 teams confirmed for the group stage.
Going into the play-off round there was a chance Rangers could progress and be a Pot 3 team. However, it required Benfica losing their qualifier with Dynamo Kyiv.
The Portuguese giants won 3-0 against he Ukrainians, completing a 5-0 aggregate success to reach the group stage.
It now means Pot 1, 2 and 3 are all secure with Rangers now knowing if they were to defeat PSV they would enter Pot 4, as the team with the highest coefficient, joining the likes of Celtic, Marseille and Club Brugge.
The Old Firm could potentially face a group of Real Madrid, Liverpool and Borussia Dortmund. Bayern Munich, Barcelona and Inter Milan is another group possibility, as is the trio of Eintracht Frankfurt, Tottenham Hotspur and Sporting CP.
The draw takes place on Thursday in Istanbul at 5pm (UK).