The Ibrox side are looking to cement their lead at the top of the Ladbrokes Championship as the quest to return to the top flight continues.
They won 5-1 in Dumfries when the teams met last August and followed it up with a 2-1 win at Ibrox in October and the home side go into the encounter having won three and lost three of their last six matches.
However, Wilson expects to face danger from the Doonhamers.
“It has been difficult in patches for them,” said the 24-year-old.
“They lost a lot of their players (in the close season) but they are coming strong again and they have good players in their squad.
“I am still good friends with Kyle Hutton (former Rangers player) and I was speaking to him and he says that they have been playing well.
“We have watched videos of them and they do knock it about well and have players who have played at the level for a long time and who are clever, so we will have to be on our guard against them.
“But we are looking forward to it, it is another chance to put three points on the board.”
Eyes will be on Palmerston’s artificial surface following the row which broke out between Rangers and Kilmarnock after Rangers striker Martyn Waghorn injured his knee at Rugby Park on Tuesday.
Waghorn went off immediately after winning and scoring a fourth-minute penalty in their 2-1 William Hill Scottish Cup fifth-round replay win and could be out for the rest of the season.
Part of the statement Rangers issued afterwards said: “The initial impact on an unforgiving Rugby Park surface resulted in bruising and lacerations which were immediately visible.”
Killie hit back at the Ibrox club, describing criticism of their surface as “ill-informed” but Rangers manager Mark Warburton subsequently called for an end to artificial surfaces in the top flight.
Wilson admits he is not a fan of plastic pitches. He said: “They have been used a lot more here and I can understand the reasons for doing so but as a player my preference is grass pitches.
“It is one of those things we need to get used to and adapt to when we play on them and not use it as an excuse.”
The former Hearts defender believes the Ibrox squad has enough strength and depth to cope with the loss of 28-goal Waghorn.
He said: “He will be a big miss. He has scored a lot of goals and fits in with the way we play.
“So it will be a blow to us but it is up to others to step into the void.
“Looking at the bench in the last couple of games and even players who haven’t been stripped, the squad is very strong.
“I am confident going forward that what we have will be enough.”