The former Rangers youngster, who has already missed a chunk of the season due to an ankle injury, was forced off the pitch after 63 minutes at Goodison Park on Tuesday after a heavy collision with team-mate and goalkeeper Jordan Pickford.
Everton boss Frank Lampard has confirmed that the 21-year-old faces six weeks out – a recovery period that would allow Patterson to return in time for the next international on March 25 when Scotland kick off their Euro 2024 qualifying campaign at home to Cyprus.
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Hide Ad"It's a blow, a freak one in terms of how he did the injury," Lampard said. "It's a big blow. He's a young full-back. He's come in, broken through and done well for us.
"It's time for others to step up to that mantle. Six weeks sounds a long time but he'll be back."