The last time a Scotland side won at Wembley was in 1999 when Don Hutchison’s first-half header secured a 1-0 win in the Euro 2000 play-offs.
However, Paul Scholes’ double in the first leg at Hampden scuppered Scottish hopes and England went on to the finals.
Steve Clarke was subjected to a bit of criticism over his team selection in the 2-0 defeat by Czech Republic on Monday and has made four changes to his team with Che Adams, Billy Gilmour, Callum McGregor, and Kieran Tierney all starting.
9. AMC - John McGinn
WIll carry a goal threat from a more advanced central position Photo: Craig Williamson - SNS Group
10. ST - Che Adams
The Southampton forward was a surpise omission from the Czech starting XI, but with his proven scoring record in the Premier League, has been restored to the starting line-up Photo: Alan Harvey - SNS Group
11. ST - Lyndon Dykes
No luck against the Czechs bur his height and physicality will be useful against England's central defence of Mings and Stones Photo: Christian Kaspar-Bartke