Prince, Princess and Coco are all under a year old and were taken from the Hallglen area of Falkirk between 7.15pm and 11.45pm on Saturday while home owner Victoria Black was away.
She returned to find that her dogs had been stolen along with a three-figure sum of money and a host Christmas presents.
Police fear the dogs may now be offered for sale by thieves.
Ms Black told the Daily Record: “I was on a Christmas night out last Saturday and left my dogs. When I came back at around 11.30pm, my front door was wide open and all three of the dogs were gone.
“I feel sick knowing that someone has been in my house, through my things and has taken the dogs from the only home they have ever known.”
Prince is described as mainly black with tan and white patches on his stomach, Coco has short ginger hair and Princess has a long ginger coat.
Appeals and pictures of the chihuahuas have been posted on dog websites and social media and their owner is offering a reward for their return.
Ms Black posted on Facebook: “These dogs are my babies and I’m asking that if anyone can help with information in the recovery of my dogs there is a reward. Please help.”
Police are investigating.
Sergeant Lyne Rushford said: “We are obviously concerned for the dogs’ welfare and would be keen to speak to anyone who was in the area at the time, or who has information that can help us trace those responsible.
“We would also ask anyone offered these dogs for sale to get in touch with us straight away.
“Anyone with information can contact Police Scotland on 101 or anonymously via Crimestoppers on 0800 555 111.”