Worcester Warriors stand-off Duncan Weir and Edinburgh trio Magnus Bradbury (back-row), winger Dougie Fife and centre James Johnstone are joined by Glasgow Warriors forwards Zander Fagerson (tighthead) and George Turner (hooker).
The sextet replaces injured Warriors duo George Horne and Stafford McDowall, who are sidelined with shoulder and ankle injuries respectively, along with front-row forwards David Cherry, Murray McCallum and Jake Kerr.
Stand-off Finn Russell, who sustained a head injury while on club duty for Racing 92 in the TOP 14 clash with Toulouse in Paris yesterday, joined up with the squad in Edinburgh on Monday.
He will undergo further tests this week ahead of the match with France after the minimum six-day recovery period. However, reports from the Scotland camp suggest the 26-year-old arrived symptom-free and could yet feature against Jacques Brunel’s side.
Forwards coach Danny Wilson said: “[Finn] is with us in the training group. Obviously it was seen that he didn’t meet the criteria to return to the field of play [for Racing 92].
“From now on it’s an assessment process. Six days from the game is Saturday and there’s a process all players go through in that period of time.
“We have just got to go with our experienced and outstanding medical staff.”
Full-back Stuart Hogg will not join the squad this week. The Glasgow back is not being considered for the match with France after sustaining a shoulder injury in the 13-22 loss to Ireland in round two of the championship.
Hogg remains under the joint care of the Glasgow and Scotland medical teams, with Scottish Rugby confirming his rehabilitation progress and review are ongoing.