The deal will see CargoLogicAir operate Boeing 747 flights on a Monday and Friday connecting with Houston’s George Bush Intercontinental Airport and Frankfurt Airport.
Each service offers 110 tonnes of freight capacity providing a boost to Scotland’s oil and gas, aerospace and manufacturing sectors.
Prestwick chief executive Stewart Adams said: “We’re extremely pleased to welcome CargoLogicAir as the airport’s latest freight operator.
“With two weekly services carrying up to 110 tonnes, this is a tremendous addition to our extensive freight handling offering – a key part of the airport’s overall commercial strategy.
“CargoLogicAir has ambitious expansion plans and utilising the services of Prestwick’s heavy-lift infrastructure, we’re excited to develop this partnership in support of its global operation.”