The national forecaster has issued a yellow weather warning for ice which could cause "some injuries from slips and falls" and "possible travel disruption" in eastern areas on Saturday morning.
Covering the eastern half of the UK including the Scottish Borders, Northumberland, Durham, North Yorkshire, the East Riding of Yorkshire and Lincolnshire, the warning lasts from midnight until 10am on Saturday.
It follows a frosty start to April across much of the UK on Friday with the mercury dropping to as low as -8C, which was recorded in Tulloch Bridge, Scotland.
While icy conditions will affect much of Scotland on Saturday, most areas will stay dry. Spells of sunshine are expected to shine across the country – particularly in West Scotland.
However, Sunday will see heavy rain accompanied by strengthening winds – although temperatures will begin to turn milder across the day.
Many areas across the country experienced snow showers earlier in the week, which are not set to return over the weekend.
The icy weather this month comes after the UK experienced its sunniest March since 1929.
New Scotland saw 64% more sun than usual, with a total of 160.1 hours.
Met Office meteorologist Dan Stroud said overnight temperatures would be several degrees colder than the average for the time of year, with cities across the UK experiencing below freezing conditions.
Mr Stroud said the wintry weather, which is being caused by Arctic air crossing the UK, is set to continue through the weekend.
He said: "It's generally dry and cold, if not slightly less cold than we have had for the next few days.
"We've got an Arctic air flow established at the moment, that's coming from a cold source.
"So we've basically got cold, clear air established across the UK.
"There's also a lot of clear and sunny skies, especially to the western parts of the UK."
Mr Stroud also said temperatures should climb from around 10C averages over the weekend to around 14C on Monday as the Arctic air system moves away.