ITV’s six-part series, called Newzoids, will include impressions by Jon Culshaw, who worked on Spitting Image, as well as the voice of Debra Stephenson.
Among the targets for its satire are David Cameron and Nick Clegg, who will be portrayed appearing on the Jeremy Kyle show, Boris Johnson, Nigel Farage and Russell Brand.
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Other famous faces that will be lampooned include geordie duo Ant and Dec, Harry Styles and Simon Cowell.
The show is co-produced by Citrus Television, which was set up by another Spitting Image veteran Giles Pilbrow.
ITV’s director of entertainment Elaine Bedell said: “ITV has a rich history of playing popular satirical comedy in peaktime on its main channel, and it seemed a good time to revive it this year. We are pleased to be adding to our growing comedy portfolio with this funny and biting look at the world of politics and celebrity.”
Spitting Image ran for more than a decade and its puppet parodies and near-the-knuckle humour made it one of the most-watched shows of the 1980s and 1990s.