Police Scotland said that junction 2 on the road towards Edinburgh has been closed.
All lanes around the junction are expected to remain closed eastbound for some time to allow collision investigation work.
This follows a single vehicle collision about 6.10pm tonight. All traffic is being diverted off at junction 2. A 31-year-old man has been taken to hospital with serious injuries.
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The M9 runs from the outskirts of the Capital, through the Falkirk area and ends at Dunblane.