Traffic is being diverted along the A70 after a one-vehicle crash near Hyndford Bridge.
Emergency services are still at the scene, and have closed the road.
It is not clear yet whether there are injuries.
A Police Scotland spokesperson said: “Officers are currently in attendance near Hyndford Bridge, Lanark, following a one-vehicle road traffic crash.
"Emergency services remain at the scene. Hyndford Road is currently closed and diversions are in place.”