The driver of a Tesla car was killed in Florida after colliding with a lorry which had turned in front of him.
Preliminary reports suggest his car’s cameras did not distinguish the white side of the trailer from the bright sky, meaning the brakes were not activated.
UK trials of automated and driverless cars are currently taking place in Bristol, Greenwich, Milton Keynes and Coventry.
In the Queen’s Speech in May it was announced that a Modern Transport Bill would include legislation to support the country becoming a world leader in driverless car technology.
AA president Edmund King claimed the accident in the US is a reminder that “driverless cars aren’t foolproof in the real world”.
He said technology “can and will enhance safety”, but went on: “We need more research into the interactions between driverless cars and driver-driven vehicles before we allow all drivers to take their hands off the wheel.”
Neil Greig, director of policy and research at road safety charity IAM Roadsmart, said: “This tragic incident appears to be an early example of the problems caused by relying on driverless systems when very few vehicles have them.
“The Tesla system arrives in the car through overnight software updates with no training offered which is clearly dangerous.
“With new UK legislation designed to encourage autonomous cars expected soon it is vital we have an open debate on the safest way to manage new technology and drivers’ ability to use it.”
US road safety officials are investigating Tesla’s auto-pilot feature following the fatal crash, which occurred on 7 May and led to the death of Joshua Brown, 40.
The system changes lanes and speeds up or slows down a car based on what other vehicles are doing.
Tesla said the death in the US was the first known fatality in over 130 million miles of autopilot operation.
It accepted that the system is “not perfect” and “still requires the driver to remain alert” with both hands on the wheel at all times.