The crash involved a lorry and a car at the Redhouse Roundabout near Kirkcaldy and Thornton.
Police saw one person was injured and taken to hospital.
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Emergency services were on the scene after the incident, which happened at around 8am today.
The westbound lane has since been reopened, but the eastbound section (towards Glenrothes) is down to a single lane.
Drivers on the road should expect delays throughout the morning while the incident is dealt with.
A spokesperson for the Scottish Ambulance Service said: “We received a call today to attend a road traffic collision on the A92 in Kirkcaldy. We dispatched one ambulance to the scene.”
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