Exposure to these household chemicals ‘increases aggressive breast cancer risk’

Some household detergents, antiseptics and insecticides are potential environmental risk factors and new targets for treating an aggressive form of breast cancer, scientists say.

According to new data, exposure to common everyday chemicals may increase the risk of developing a difficult-to-treat type of breast cancer.

However, experts say that, while the study has no clinical or public health implications, it identifies areas for new research.

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Triple negative breast cancer (TNBC) is an aggressive form that particularly affects younger people and makes up 10-20 per cent of all breast cancer diagnoses.

A woman undergoes a screening test for breast cancerA woman undergoes a screening test for breast cancer
A woman undergoes a screening test for breast cancer

While curable if caught early, TNBC is resistant to hormone treatments and newer targeted therapies used to treat other types of breast cancer.

It is therefore treated with surgery, radiotherapy and chemotherapy.

Researchers say there is a better need to understand the biology of this aggressive form of breast cancer in order to develop new therapies, improve quality of life and identify how to reduce the risk of developing it.

Women with other types of breast cancer that are hormone receptor positive are treated with hormonal therapies which target oestrogen and progesterone receptors – two of 48 nuclear receptors (NRs).

It is known that many NRs are altered in breast cancer. This means they can be potential drivers of breast cancer development and possible therapeutic targets.

The receptors act as environmental sensors, working together to control different aspects of how breast and other tissues work.

But how environmental chemicals change their activity is not well known, especially in the context of TNBC. Dr Laura Matthews and Professor Chris Twelves from the University of Leeds, with Professor Valerie Speirs from the University of Aberdeen, led a study funded by charity Breast Cancer UK.

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They mapped the entire NR superfamily in 68 breast cancer samples and from normal breast tissue, to identify common alterations in NR activity.

Comparing their findings with those from other studies to identify NRs associated specifically with TNB, they were able to predict which drugs or environmental chemicals are more likely to generate the distinct NR profiles associated with TNBC.

In the abstract presented at the Society for Endocrinology annual conference in Brighton, they said these include disinfectants, insecticides, dietary fats and industrial pollutants.

Dr Matthews said: “Our goal is to reduce the number of people that develop breast cancer, and guide new therapies, so that more people can live beyond breast cancer.”

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