The tweet, now deleted and resent to the Prime Minister’s account, read: “@TheresaMay, don’t focus on me, focus on the destructive Radical Islamic Terrorism that is taking place within the United Kingdom. We are doing just fine!”
Most of the responses offered their condolences to the first woman, with many Americans apologising for the actions of their president.
“Sorry for @POTUS putting you on the spot like that,” wrote one user.
“Sorry about @realDonaldTrump #LeaveTheresaAlone,” added another.
It was not the first time the user has been mistaken for the Prime Minister, however, as she appears to receive almost daily tweets from Twitter users asking her to fix the NHS or speed up the Brexit process.
Neither was it the first time Mr Trump has directed his 44 million followers to the wrong account.
In January he mistakenly tagged a woman from Brighton in a tweet instead of his own daughter.
Quoting an account which has since been suspended, her wrote: “@Ivanka Trump is great, a woman with real character and class.”
The owner of the @Ivanka account, a digital consultant from Brighton, replied: “And you’re a man with great responsibilities. May I suggest more care on Twitter and more time learning about #climatechange.”