The comments from the First Minister on Tuesday came the day after the publication of an ‘update’ report from the civil servant Sue Gray into parties across government in London.
The report, which was only 12 pages due to a request from the Metropolitan Police to make “minimal reference” to events it is investigating, concluded there was a “failure of leadership” around the gatherings.
It also confirmed 12 out of the 16 parties investigated by Sue Gray are being investigated by officers, including one event in the Number 10 flat.
During a Covid-19 update in Holyrood, the SNP backbencher Evelyn Tweed asked the First Minister whether she had concerns the actions of Boris Johnson were eroding and undermining public confidence in decision makers.
Ms Sturgeon said she “obviously” had concerns around that following the publication of the Gray report.
She said: “I think there is very little public trust remaining in the integrity and the decision making of the Prime Minister and his Government over these matters.
“I think it is now impossible to reach any conclusion other than the Prime Minister has seriously and serially misled the House of Commons.
"I think it is always important and I have had cause over the past year or so to reflect very carefully on these things myself. It is really important that what people like me and the Prime Minister say in chambers of Parliament can be trusted, but that is never more important than during the times of crisis that we are living through.”
Her comments came just minutes after the results of a new poll, conducted by Savanta ComRes prior to the publication of the Gray report, showed an 11 point lead for Labour ahead of the Conservatives.
The poll interviewed 2,283 UK adults between January 28 and 30, and saw Labour receive a vote share of 44 per cent, with the Conservatives in second on 33 per cent.