Speaking in his keynote speech to conference, Sir Keir is expected to tell members that only his party can deliver change on issues such as the cost-of-living crisis.
He is expected to say: “Scotland needs a Labour government that can deliver change.
“But it also needs to power and resources to shape its own future, whoever’s in power in Westminster.
“And the SNP are not interested in this. For them, Scotland’s success in the UK is met with gritted teeth, seen as a roadblock to independence. And so they stand in the way.”
He will add: “Labour will deliver change. You will never get that from the Tories. And you won’t get it from the SNP either.
“The challenges we face: the cost-of-living crisis, climate change, standing up to Putin; are common across our four nations.
“We saw off the threat of fascism and deadly disease, together. We built the NHS and the welfare state, together.
“But I don’t believe in our union just because of our history. I believe in it because of our future.
“I know we can meet the great challenges to come. Build new beacons of fairness that light up the islands we share.”
His comments come as the Labour leader has reiterated his refusal to work with the SNP to form a government – even if it means his party have to form a minority government.
The two parties clash on the issue of holding a second referendum on Scottish independence.
He is expected to address the issue in his keynote speech. He will say: “We can’t work with them, we won’t work with them. No deal under any circumstances.”
The Labour leader will also use his speech to the party conference in Liverpool on Tuesday to commit to getting the UK “out of this endless cycle of crisis” with a “fresh start”.
He will argue Labour is now the party of “sound money” and recommit the party to an office for value for money to ensure taxpayers’ money is spent in the national interest.