The Scottish Ambulance Service confirmed that the four involved in the crash have been taken to Ninewells Hospital in Dundee
Their condition is not yet known.
A Scottish Ambulance spokesperson said: “We received a call at 1409 hours today to attend a road traffic collision on the A9 at Aberuthven.
"We transported four patients to Ninewells Hospital."
Police Scotland officers are currently at the scene after they received reports of the crash at around 2pm today on the A9 near Aberuthven.
A Police Scotland spokesperson said: "Officers were called to reports of a two vehicle crash on the A9 near Aberuthven around 2.05pm on Friday 5 March 2021.
"Officers are currently at the scene."
Traffic Scotland reported that the A9 soutbound at Aberuthven which was closed due to the collision has now been cleared.
More to follow.