Sir Anthony is a keen painter and this exhibition will comprise mainly portraits and landscapes.
The actor, best-known for playing serial killer Hannibal Lecter, said: "When I paint, I just paint freely without anxiety regarding outside opinions as criticisms. I do it for sheer pleasure. It's done wonders for my for my subconscious – I dream now in colours."
The collection will be shown in The Dome, George Street, from 2-6 March.
Jonathan Poole, the exhibition's organiser, said: "It is very exciting to have Sir Anthony Hopkins' work."