An 18in trunk main burst in the early hours of Monday morning in Deanston Drive, causing interruption to water supplies in the Shawlands area.
The incident has also caused localised flooding around Tantallon Road.
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Hide AdScottish Water warned customers in the area affected will experience discoloured water and lower than normal water pressure.
A spokesperson for the company said a team of engineers is on site to find the burst and begin restoring water supplies.
The spokesperson added: “We would encourage any customers who have experienced flooding and who need support to call us on 0800 077 8778.”