Dogs Kingston and Jake are both in the care of the charity’s Edinburgh and Lothians Animal Rescue and Rehoming Centre in Balerno.
Staff are appealing for committed owners to offer them permanent homes where they will receive the special care and attention they need.
Centre manager Diane Aitchison said: “Kingston is a stunning big akita aged five years old.
“Sadly he is almost completely blind in both eyes and needs eye drops daily, which will likely be a requirement for the rest of his life.
“Despite having practically no sight, Kingston loves going for walks and uses his hearing and sense of smell to help him when he’s out and about.
“We think he should learn to navigate around his new house without any problems as he quickly works out where he is and remembers where things such as doorways and furniture are located.
“Jake is a handsome English bull terrier aged seven years old. He’s a really friendly and good natured boy who is completely deaf.
“His new owner will have to train him to understand their hand signals for commands.
“Jake is very observant and is always watching to see what’s happening so this will make the training much easier.
“Deaf and blind dogs are really dependent on their owners and this creates a very strong bond. We are looking for caring owners who understand the needs of a deaf and blind dog and will ensure they settle into their new homes.
“Kingston and Jake are such amazing boys and their new families will have a truly rewarding and happy life with them.
“Our staff here will be happy to offer advice to anyone interested in taking on one of these wonderful dogs.”
Anyone who can offer Jake or Kingston a new home is being asked to contact the Scottish SPCA’s Edinburgh centre on 03000 999 999.