The Scottish experts also think the switch might play a role in chronic pain and psychosis. Aberdeen scientists believe the findings might be a step towards the development of personalised therapies.
The team from the University’s Kosterlitz Centre for Therapeutics studied genetic differences around the gene CNR1. Dr Alasdair MacKenzie said: “Our study is one of the first to explore the possibility that changes in gene switches are involved in causing side-effects to drugs. We believe this approach will be crucially important in the future development of more effective personalised medicine, with fewer side-effects.”