It is the first time daily reported cases have risen above 100,000.
The Government said a further 140 people had died within 28 days of testing positive for Covid-19.
Separate figures published by the Office for National Statistics show there have now been 173,000 deaths registered in the UK where Covid-19 was mentioned on the death certificate.
A total of 51,577,782 first doses of Covid-19 vaccine had been delivered in the UK by December 21. This is a rise of 39,955 on the previous day.
Some 47,156,899 second doses have been delivered, an increase of 54,085.
A combined total of 30,844,888 booster and third doses have also been given, a day-on-day rise of 968,665.
Separate totals for booster and third doses are not available.
A total of 8,008 people were in hospital in the UK with Covid-19 as of December 21.
This is the highest number since November 22 and is up 4 per cent from a week earlier.
During the second wave of coronavirus, hospital numbers peaked at 39,254 on January 18.