Danny Care and Andrew Saull both scored two tries as England's teenage stars impressed with some sharp finishing. Leeds Tykes scrum-half Care and Saracens flanker Saull both struck in the first half as their side built up an impressive lead under the astute direction of Wasps and Whitgift playmaker Danny Cipriani.
They didn't manage to run riot in the second-half but Leicester wing Oliver Dodge - son of former England centre Paul - claimed a well-taken try and Cipriani stroked over a fourth conversion to add to his first-half penalty.
Scotland fought back with the last move of the match to register their only score when they overloaded England on the left for Edinburgh wing David McCall to slide over.
Meanwhile, the Scotland Women's coach Gil Stevenson wants his side to play without pressure against England tonight as they search for the first win of their Six Nations campaign.
The women will take to the Murrayfield pitch following the men's game on the back of defeats to France (23-3) and Wales (5-0) in recent weeks and Stevenson feels the players have been putting too much pressure on themselves.
The coach, who has added nine new players to the starting line up, said: "The girls are such a hard-working bunch that they get frustrated when things don't go well and they get stressed out. They just need to relax instead of trying to force the issue."
Full-back Lucy Millard and captain and scrum-half Paula Chalmers - the latter will be winning her 70th cap - are the only players to remain in the same berths from the last international against Wales.
Scotland Women (to play England at Murrayfield tonight, 7.15pm): L Millard; M Christie, K Davies, V Fitzpatrick , R Shepherd; R Petlevannaya, P Chalmers; L Reid, V Wiseman, G Russell, L Cockburn, L Wheeler, S Brown, D Kennedy, S Watt. Subs: I Frickleton, K Findlay, S Mee, C Muir, MP Tierney, C Ovenden, L Douglas.
England Women: S Day, N Crawford, M Staniford, K Oliver, D Waterman; K Andrew, J Yapp; R Clark, S Rudge, V Gray, J Sutton, R Vickers, G Stevens, C Spencer, M Alphonsi. Subs: A Garnett, V Huxford, T Taylor, H Clayton, S Rae, C Barras, V Massarella.
A International: France 44, Italy 6.
Under-21 Six Nations: Scotland 22, England 49; France 51, Italy 5; Ireland 13, Wales 14.
Under-19 Six Nations: England 36, Scotland 5.
BT Premiership Division 2: Kelso 47, Murrayfield Wanderers 7.
Guinness Premiership: Newcastle 24, Leicester 16; Leeds 21, Worcester 15.