In the 100m butterfly, Edinburgh University's Iain Macmillan also finished well outside the medals. He was eighth in 55.73 secondss and was more than three seconds adrift of the winner, Michael Rock (53.66).
Warrender's Lewis Smith, who was a disappointing fourth in the 400m individual medley, was eight over his less-favoured 200m distance. England's James Goddard won in 1:57.76 and Smith clocked 2:04.48.
Double Olympic champion Rebecca Adlington claimed her expected victory in the 400m freestyle, but the huge disappointment was the withdrawal of her main rival, Jo Jackson.
The Olympic bronze medallist has had her winter training severely disrupted by asthma and she had another serious attack after the morning heats.
She pulled out on doctor's advice and it means that she has not qualified for the European Championships in Budapest in August.
Adlington, with the 200m and 800m already secured, took the title in 4:05.50, a comfortable four seconds ahead of Wales' Jaz Carlin. England's Sasha Matthews, the silver medallist behind Adlington in the 800m, was third.
The former City of Edinburgh swimmer, Megan Gilchrist, who is now based in Swansea, also made the final but had to settle for sixth place in 4:15.24. The 18-year-old from West Lothian was fourth in the 800m freestyle on Thursday.