The home side drew with Ireland last weekend while Scotland were beaten by England in the Calcutta Cup clash at BT Murrayfield. Here’s all you need to know ahead of the match in the Welsh capital...
Kick-off time: 4.50pm
Where to watch: BBC1 from 4.30pm
Wales team (15-1): Liam Williams; George North, Jonathan Davies, Jamie Roberts, Tom James; Dan Biggar, Gareth Davies; Taulupe Faletau, Justin Tipuric, Sam Warburton; Alun Wyn Jones, Luke Charteris; Samson Lee, Scott Baldwin, Rob Evans. Replacements: Ken Owens, Gethin Jenkins, Tomas Francis, Bradley Davies, Dan Lydiate, Lloyd Williams, Rhys Priestland, Gareth Anscombe.
Scotland team (15-1): Stuart Hogg; Sean Maitland, Mark Bennett, Duncan Taylor, Tommy Seymour; Finn Russell, Greig Laidlaw; David Denton, John Hardie, John Barclay; Jonny Gray, Richie Gray; WP Nel, Ross Ford, Alasdair Dickinson. Replacements: Stuart McInally, Gordon Reid, Zander Fagerson, Tim Swinson, Blair Cowan, Sam Hidalgo-Clyne, Duncan Weir, Sean Lamont.
Referee: George Clancy (IRFU)
Key players: Jamie Roberts, Alun Wyn Jones, Liam Williams (Wales). Jonny Gray, Stuart Hogg, Duncan Taylor (Scotland)
Last five meetings: Scotland 23-26 Wales; Wales 51-3 Scotland; Scotland 18-28 Wales; Wales 27-13 Scotland; Scotland 6-24 Wales.
Odds: Wales 1/5 Draw 25/1 Scotland 7/2
What Wales are saying: “I am really looking forward to it. Scotland present a difficult challenge and they were a bit unlucky last weekend against England. If we don’t get our stuff right then we are going to be in for a tough day.” (Dan Biggar, Wales outside-half)
What Scotland are saying: “We came last last year. So we’re looking to improve on that and let’s wait until the end of the competition to see if we have. We lost by six points to England, we’re going to play in Wales, where two years ago it was a pretty difficult game, I think – we’d like to do better than that.” (Vern Cotter, Scotland head coach)